منابع مشابه
Synergistic Effect of CTLA-4 Blockade and Cancer Chemotherapy in the Induction of Anti-Tumor Immunity
Several chemotherapeutics exert immunomodulatory effects. One of these is the nucleoside analogue gemcitabine, which is widely used in patients with lung cancer, ovarian cancer, breast cancer, mesothelioma and several other types of cancer, but with limited efficacy. We hypothesized that the immunopotentiating effects of this drug are partly restrained by the inhibitory T cell molecule CTLA-4 a...
متن کاملImproved anti-tumor immunity and efficacy upon combination of the IDO1 inhibitor GDC-0919 with anti-PD-l1 blockade versus anti-PD-l1 alone in preclinical tumor models
Improved anti-tumor immunity and efficacy upon combination of the IDO1 inhibitor GDC-0919 with anti-PD-l1 blockade versus anti-PD-l1 alone in preclinical tumor models Jessica Spahn, Jing Peng, Edward Lorenzana, David Kan, Thomas Hunsaker, Ehud Segal, Mario Mautino, Erik Brincks, Andrea Pirzkall, Sean Kelley, Sami Mahrus, Liling Liu, Stephanie Dale, Cristine Quiason, Elizabeth Jones, Yichin Liu,...
متن کاملRUNX3 methylation and anti-tumor immunity.
Altered DNA methylation is a hallmark of cancer genomes and has been advocated as both a marker and mechanism of the malignant phenotype. In the conventional view, such alterations include global DNA hypomethylation, linked to aberrant expression of oncogenic driver genes and more localised de novo hypermethylation at ‘CpG-island’ promoters, argued to cause inappropriate silencing of tumor supp...
متن کاملEngineering Anti-Tumor T Cell Immunity
T cell immunity is critical for protection against infectious agents as well as cancer. T cell immune response is a well orchestrated process that involves three key components. CD8+ T cells that harbor cytolytic machinery and can target and kill the tumor cells in an antigen specific manner, CD4+ T cells that can either “help” the generation of a productive CD8+ T cell or “regulate/suppress” i...
متن کاملHost CD73 impairs anti-tumor immunity
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.
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ژورنال
عنوان ژورنال: Immunity
سال: 2020
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2020.01.015